Nia Therapeutics develops implantable, closed-loop neuromodulation systems designed to target memory dysfunction. The company’s Smart Neurostimulation System (SNS) records neural activity from distributed brain networks involved in memory and delivers adaptive stimulation based on decoded brain states. Its approach focuses on restoring network-level dynamics rather than targeting localized pathological signals.

The SNS is a wireless, implantable system capable of sensing neural activity across multiple brain regions simultaneously and using real-time decoding to guide stimulation delivery. By integrating multi-channel recording with algorithm-driven control, the platform is designed to support modulation of memory-related brain states in a personalized manner. The system emphasizes distributed sensing, adaptive control, and chronic implantation for long-term use.

Nia Therapeutics is initially targeting memory impairment following traumatic brain injury, with planned first-in-human studies informed by prior human research on closed-loop stimulation and recent large-animal validation. The platform is positioned within translational neurotechnology and investigational neuromodulation, with a focus on conditions where existing pharmacological and stimulation approaches have shown limited functional benefit.