STARTUP PROFILE

CraniUS Therapeutics

COUNTRY
USA
FOUNDED
2021
CATEGORY
Tools and Infrastructure
Developing a skull-embedded, pump-driven intracranial drug delivery platform designed for repeatable, targeted convection-enhanced infusion beyond the blood-brain barrier.
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Neurofounders Insights
$   Funding   -
Series A
MODALITY
Others
FORM FACTOR
Implant
INTERFACE DEPTH
Implantable
INDICATION
Tumors
TARGET USER
Clinicians
REGULATORY STAGE
Preclinical
CraniUS Therapeutics targets a specific bottleneck in CNS drug delivery with its implantable convection-enhanced delivery system, enabling repeated, localized dosing beyond the blood–brain barrier. This positions it as enabling infrastructure for neuro-oncology therapies rather than a standalone therapeutic company.
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MOST RECENT COVERAGE
#
5
New Clearances and Stronger Coverage
7 July – 21 July 2026

CraniUS received an initial $1.1M award from the NIH Blueprint MedTech program, with the potential to increase to $4M. The Baltimore company builds NeuroPASS, a fully implantable, skull-embedded device designed to bypass the blood-brain barrier and deliver drugs directly into brain tissue. The funding supports engineering, manufacturing, and regulatory work toward a first-in-human study. The first application explored is recurrent glioblastoma, the most common malignant primary brain tumour in adults.

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CraniUS Therapeutics