Zeta Surgical develops image-guided navigation systems for brain surgery, interventional neurology, and neuromodulation targeting. Its platform is designed to support cranial procedures across operating rooms, outpatient settings, and point-of-care environments where real-time guidance can improve procedural accuracy.

The system uses computer vision, AI image analysis, and frameless navigation to align preoperative CT or MRI scans with patient anatomy. Public materials describe applications including brain biopsy, external ventricular drain placement, hydrocephalus procedures, trigeminal neuralgia workflows, and navigated TMS targeting. Zeta has received FDA 510(k) clearances for its navigation system, navigated instruments, and TMS navigation system.

Zeta targets clinicians and health systems performing cranial procedures and precision neurotherapeutic workflows. The company is best understood as a cleared clinical navigation infrastructure provider for neurosurgery and targeted brain intervention.