STARTUP PROFILE

Motif Neurotech

COUNTRY
USA
FOUNDED
2022
CATEGORY
Neuromodulation
Developing minimally invasive, battery-free brain implants (DOT) that wirelessly stimulate brain circuits to treat treatment-resistant depression.
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Neurofounders Insights
$   Funding   -
Series A
MODALITY
Others
FORM FACTOR
Implant
INTERFACE DEPTH
Implantable
INDICATION
Psychiatry
TARGET USER
Patients
REGULATORY STAGE
Investigational
Motif Neurotech is differentiated by its tiny, battery-free, minimally invasive implant architecture for depression, targeting a gap between external psychiatric neuromodulation and larger implanted systems. Its hardware elegance is a strong narrative advantage, though clinical proof remains early.
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MOST RECENT COVERAGE
#
1
Tracking Neurotech Startups
1 May – 26 May 2026

On May 1, Motif announced a multi-year semiconductor supply partnership with MintNeuro, securing purpose-built low-power neural interface chips for its DOT implant platform. The announcement followed Motif's late-April FDA clearance to begin RESONATE, its first clinical trial for treatment-resistant depression. Locking in a dedicated IC supply arrangement this early suggests the company is building toward pivotal scale. Motif's implant operates under strict power and size constraints that off-the-shelf components are not designed to meet.

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Motif Neurotech