Cognito Therapeutics, a late clinical-stage neurotechnology company pioneering non-invasive therapies for neurodegenerative diseases, today announced new research from its investigational Spectris™ therapy at the AD/PD™ 2026 International Conference on Alzheimer’s and Parkinson’s Diseases, held March 17–21 in Copenhagen, Denmark.

The presentations explore how gamma sensory stimulation delivered through the Spectris™ system may influence brain network activity and electroencephalography (EEG) biomarkers associated with Alzheimer’s disease.

One oral presentation reported a detailed analysis of EEG, MRI and clinical outcomes from the company’s OVERTURE feasibility study in patients with mild-to-moderate Alzheimer’s disease. The analysis evaluated longitudinal Spectris-induced changes in brain network activity and their relationship to measures of cognition, daily function, and structural brain preservation.

Participants in the OVERTURE study exhibited well-established EEG abnormalities in spectral power distribution characteristic of Alzheimer’s disease, and baseline EEG metrics were comparable between active and sham groups. Over the 24-week treatment period, patients treated with Spectris demonstrated attenuation of shifts in EEG power spectra from higher to lower frequencies, commonly referred to as EEG slowing, compared with sham-treated participants.

Importantly, reductions in EEG slowing in the active treatment group correlated with reduced decline in the total ADCS-ADL score and reduced MRI brain volume loss, suggesting that neurophysiological changes measured by EEG may indicate clinically relevant treatment outcomes.

“These findings provide additional evidence that gamma sensory stimulation has the potential to modulate brain network activity in ways that may be clinically meaningful for patients with neurodegenerative disease,” said Christian Howell, Chief Executive Officer, Cognito Therapeutics. “By linking changes in electrophysiological biomarkers with functional and structural outcomes, this research helps deepen our understanding of how Spectris may influence the underlying biology of Alzheimer’s disease.”

Additional poster presentations explore the effects of gamma sensory stimulation on cognitive event-related potentials (ERPs), demonstrating that Spectris stimulation can enhance neural responses associated with working memory and cognitive processing in patients with Alzheimer’s disease.

The research builds on results from the OVERTURE randomized, sham-controlled clinical study evaluating Spectris in patients with mild-to-moderate Alzheimer’s disease. EEG biomarkers from that study are also being incorporated into the company’s ongoing HOPE pivotal trial, where EEG will be evaluated as a potential quantitative biomarker to provide supportive mechanistic evidence for the trial’s primary composite endpoint assessing daily function and cognition.