eNeura is a Sunnyvale, California-based medical device company developing single-pulse transcranial magnetic stimulation (sTMS) for the treatment and prevention of migraine. The company's sTMS mini device is a portable, handheld device that delivers a single focused magnetic pulse to the posterior cortex during a migraine attack or as a preventive treatment.

The sTMS mini received FDA clearance and CE marking for acute treatment of migraine with aura and migraine prevention. The mechanism of action involves disrupting cortical spreading depression, the underlying electrophysiological event associated with migraine aura, using a single high-intensity magnetic pulse. Unlike multi-pulse rTMS systems, single-pulse sTMS for migraine does not require the same clinical supervision as psychiatric TMS therapy and can be self-administered at home.

The device targets the approximately 3 million migraine sufferers in the US who have not responded to oral medications, positioning itself between drug treatments and invasive neuromodulation approaches.