Inside

Cognitive and Mental Health

Technologies that apply
neuroscience, brain-related signals,
and cognitive science to monitor, assess,
or improve mental health and cognitive function through digital, sensor-based, and
AI-driven systems.
Explained
Cognitive and mental health neurotech sits at the intersection of neuroscience, digital health, and artificial intelligence. Rather than relying solely on direct neural interfaces or implanted devices, this category focuses on extracting brain-relevant signals from behavior, physiology, and neuro-aware sensors to generate objective measures of mood, stress, cognition, and mental state.

These technologies encompass a wide spectrum, including passive monitoring via speech, movement, or smartphone usage; wearable biosensors such as EEG or physiological trackers; and software platforms that apply machine learning to derive digital mental health biomarkers. In many cases, they blend continuous background sensing with active interventions such as neurofeedback, cognitive training, or adaptive digital therapeutics.

Over the past decade, the field has shifted away from subjective self-report and standalone wellness apps toward more data-driven, clinically informed approaches. Advances in affective computing, digital biomarkers, and regulatory recognition of software-based diagnostics have enabled mental health tools that can support screening, monitoring, and treatment at scale.

As of 2026, this category spans both regulated medical applications and consumer-facing brain health platforms, with increasing emphasis on validation, longitudinal data, and integration into healthcare workflows. While the boundary between wellness and clinical care remains fluid, cognitive and mental health neurotech is increasingly positioned as a foundational layer for personalized, measurement-driven mental healthcare.
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Domains

Voice and Speech Analytics

AI models analyze acoustic features of natural speech such as pitch, cadence, hesitation, and energy to infer mood, cognitive load, and neurological status. These systems are largely language-agnostic and passive, making them suitable for scalable screening, longitudinal monitoring, and digital endpoints in clinical trials.

Mobile-Based Digital Phenotyping

Passive data collected from smartphones and wearables, including typing dynamics, movement patterns, sleep, and device interaction behavior, is used to infer changes in mental state or cognition. These approaches prioritize longitudinal trend detection rather than real-time diagnosis and are often positioned as early-warning or monitoring tools.

EEG-Based Wearables and Neurofeedback

Consumer and research-grade EEG headsets enable measurement of brain activity outside clinical settings, often paired with real-time neurofeedback. By translating neural signals into auditory, visual, or game-based feedback, these systems aim to support self-regulation of attention, stress, or emotional state over repeated training sessions.

Optical and Hybrid Brain Monitoring

Wearable optical sensors measure cortical blood oxygenation as a proxy for neural activity, sometimes combined with EEG for complementary temporal and spatial insight. These systems are increasingly used for cognitive training, mental workload monitoring, and hybrid neurofeedback applications.

Peripheral Physiological Biomarkers (HRV, GSR, Sleep)

Signals from the autonomic nervous system, including heart rate variability, skin conductance, respiration, and sleep metrics, are modeled to infer stress, arousal, and emotional regulation capacity. These modalities are widely used for both real-time biofeedback and longitudinal mental health monitoring.

Neuroadaptive and Multisensory Interfaces

Audio, visual, or haptic stimuli are dynamically adjusted based on user state or neuro-informed rules to influence cognition or emotional regulation. Examples include adaptive soundscapes, rhythmic light stimulation, and vibrotactile wearables designed to entrain neural or autonomic responses.

Cognitive Assessment and Digital Tasks

Neuroscience-informed cognitive tests and games are used to assess attention, memory, executive function, and processing speed. Performance metrics, often augmented by AI, serve as behavioral proxies for brain function and are used in screening, monitoring, and in some cases as digital therapeutics.

Multimodal Mental Health Platforms

Integrated systems that combine multiple signals such as voice, behavior, physiology, and brain data to improve robustness and personalization. These platforms increasingly position themselves as decision-support layers for clinicians or as precision mental health tools that move beyond single-signal inference.
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Startups

Alto Neuroscience

Developing precision psychiatric medicines by leveraging neurobiology to predict and improve treatment response.
USA
Cognitive and Mental Health

Decision Support

Therapeutics

BrainCheck

Providing a software-based cognitive assessment platform for rapid screening, monitoring, and diagnosis support across neurological and mental health conditions.
USA
Cognitive and Mental Health

Diagnostics

Clinical Workflows

Cognoa

Providing AI-powered tools (Canvas Dx) for rapid, equitable autism diagnosis in young children, and is developing digital therapeutics to improve behavioral health
USA
Cognitive and Mental Health

Pediatric

Diagnostics

EVOCAL Health

Unlocking voice as a predictive biomarker using AI to detect diseases and support digital diagnostics and therapies across Longevity and neurodegeneration.
Germany
Cognitive and Mental Health

Diagnostics

Data Infrastructure

Ellipsis Health

Analyzing natural speech to detect depression and anxiety through empathetic AI voice agents, enabling scalable mental health screening.
USA
Cognitive and Mental Health

Diagnostics

Machine Learning

GrayMatters Health

Developing Prism, an FDA-cleared neurofeedback system using EEG-based biomarkers to train self-regulation of brain networks in PTSD and depression.
Israel
Cognitive and Mental Health

Therapeutics

Closed-loop

Kinesix XR

Delivering immersive AI‑driven VR/AR therapy platform offering personalized neurorehabilitation exercises to improve motor and cognitive recovery.
Canada
Cognitive and Mental Health

AR/VR

Machine Learning

Kintsugi

Detecting signs of depression and anxiety from just seconds of speech, using AI-powered voice biomarkers to enhance mental health diagnosis.
USA
Cognitive and Mental Health

Diagnostics

Machine Learning

MindAffect

Providing EEG-based neurofeedback and brain training solutions to support mental health and cognitive regulation.
Netherlands
Cognitive and Mental Health

Therapeutics

Wellness

NeuraLight

Extracting eye-movement biomarkers via AI and computer vision from standard webcams or smartphones to accelerate CNS drug development and neurology diagnostics.
Israel
Cognitive and Mental Health

Machine Learning

Decision Support

NeuroBrave

Developing a hardware-agnostic AI software platform that converts wearable biosensor data into real-time cognitive and emotional state insights.
USA
Cognitive and Mental Health

Machine Learning

Decision Support

Neurocast

Passively monitoring brain health via AI-based keystroke and smartphone behavior analysis, delivering real-world neurological data non-invasively.
Netherlands
Cognitive and Mental Health

Diagnostics

Machine Learning

Neurode

Offerign a wearable, drug-free headband that stimulates and tracks brain activity for managing ADHD symptoms in just 20 minutes daily.
Australia
Cognitive and Mental Health

Therapeutics

Experimental

Neurotrack

Providing digital cognitive assessments that use eye-tracking and AI to deliver fast, validated screening for dementia and Alzheimer’s risk.
USA
Cognitive and Mental Health

Diagnostics

Aging

Neuroventis

Empowering epilepsy and migraine patients with mobile apps (Helpilepsy, MigraineManager) for logging symptoms and safely sharing data with their neurologists.
Belgium
Cognitive and Mental Health

Monitoring

Clinical Workflows

Neurowyzr

Developing a digital cognitive training platform that uses neuroscience-informed tasks to support mental performance and brain health.
Singapore
Cognitive and Mental Health

Monitoring

Wellness

PigPug Health

Building wearable EEG + AI-powered neurofeedback platform for children with ADHD/ASD to improve attention and learning without medication.
USA
Cognitive and Mental Health

Pediatric

Wellness

Rune Labs

Providing a cloud-based AI platform (StrivePD) that transforms smartphone and wearable neurology data into actionable insights for precision neurology.
USA
Cognitive and Mental Health

Monitoring

Clinical Workflows

SOMAREALITY

Developing eye-tracking–based algorithms to extract neural signals and monitor cognitive processes in real time.
Austria
Cognitive and Mental Health

Monitoring

Sana Health

Delivering a wearable audiovisual neuromodulation mask that uses light and sound pulses via HRV feedback to reduce chronic pain, improve sleep, and ease anxiety.
USA
Cognitive and Mental Health

Therapeutics

Monitoring

Senseye

Developing eye-tracking–based neurodiagnostic software to objectively assess brain function and support early detection of neurological disorders.
USA
Cognitive and Mental Health

Diagnostics

Decision Support

Syntropic

Using 60 Hz non-invasive light stimulation via the eyes to trigger microglia-mediated neuroplasticity, offering a fast, drug-free option for depression and brain recovery.
Austria
Cognitive and Mental Health

Experimental

Therapeutics

Thymia

Developing digital biomarkers from speech, video, and gameplay to assess and monitor depression and related mental health conditions.
UK
Cognitive and Mental Health

Diagnostics

ViewMind

Enabling non-invasive, VR headset-based assessment of neurocognitive health using eye movement biomarkers with high sensitivity and specificity.
USA
Cognitive and Mental Health

Diagnostics

AR/VR

Vistim Labs

Providing AI-powered EEG brain mapping software that enables point-of-care monitoring of dementia, correlating with amyloid, tau, atrophy, and cognitive endpoints.
USA
Cognitive and Mental Health

Monitoring

Aging

Wave Neuroscience

Using EEG-driven brain mapping and personalized neuromodulation protocols to optimize neural activity for cognitive and mental-health outcomes.
USA
Cognitive and Mental Health

Clinical Workflows

Therapeutics

Winterlight Labs

Analyzing natural speech via tablet to extract vocal biomarkers that detect and monitor cognitive impairment, enabling objective, scalable assessments.
Canada
Cognitive and Mental Health

Diagnostics

Aging

Zander Labs

Developing portable, high-fidelity EEG hardware and passive BCI systems for real-time cognitive monitoring and neuroadaptive applications.
Netherlands
Cognitive and Mental Health

Decision Support

Machine Learning