The Bill & Melinda Gates Foundation is one of the world's largest private foundations, based in Seattle. It focuses primarily on global health, poverty alleviation, and education. In neuroscience and neurological disease, the Gates Foundation has funded Alzheimer's research through the Dementia Discovery Fund ($50M contribution from Bill Gates personally) and supported global neurological disease burden work. The Foundation also backs neuroscience diagnostics relevant to global health through its Grand Challenges programs. Its relevance to commercial neurotech is selective — most relevant for global health-oriented neurotech applications, infectious disease neurological sequelae, or diagnostics relevant to low-resource settings.