STARTUP PROFILE

Neurolief

COUNTRY
Israel
FOUNDED
2014
CATEGORY
Neuromodulation
Delivers wearable, at-home neuromodulation via Relivion, stimulating multiple cranial nerve branches to relieve migraine and depression.
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Neurofounders Insights
$   Funding   -
Seed
MODALITY
Nerve stimulator
FORM FACTOR
Headset/cap
INTERFACE DEPTH
Non-invasive
INDICATION
Psychiatry
TARGET USER
Patients
REGULATORY STAGE
FDA approved (PMA)
Neurolief is differentiated by its multi-branch cranial nerve stimulation headset, positioning Relivion as a more distributed neuromodulation approach than single-nerve wearables. Its approval pathway and at-home use case give it stronger commercial grounding than many consumer-adjacent stimulation products.
Mentioned in Market Notes
MOST RECENT COVERAGE
#
7
Measuring What Works
4 August – 18 August 2026

Neurolief secured a US Department of Veterans Affairs contract to bring two prescription neuromodulation therapies to veterans: Proliv Rx for treatment-resistant depression and Relivion MG for acute migraine. Both are non-invasive, self-administered at home under physician supervision, and stimulate branches of the occipital and trigeminal nerves through a head-worn device. The VA is the largest integrated health system in the US, serving nine million veterans, among whom depression and migraine are especially common. In the pivotal depression trial, remission reached 21.3% with active therapy against 6% for sham.

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Neurolief