3Brain provides advanced microelectrode array technology for recording neural activity at high spatiotemporal resolution in laboratory settings. The company builds CMOS-based HD-MEA (high-density multi-electrode array) systems that can simultaneously monitor hundreds to thousands of neurons in cell cultures, brain organoids, or acute brain slices, enabling researchers to observe network dynamics and identify electrophysiological biomarkers in vitro.

3Brain’s flagship platform consists of plates or chips embedded with grids of tiny electrodes (up to 1024 per chip) at micrometer-scale spacing. Biological samples like neuronal cell cultures or tissue slices are placed on these electrode arrays. Each electrode can pick up the electrical signals (spikes and local field potentials) from nearby neurons, and the system digitizes and streams this data for analysis on a connected software suite. With such density, the platform achieves single-cell resolution and can map how neurons fire and interact in both 2D and 3D tissue models. 3Brain also provides integrated software (BrainWave) to visualize and analyze this high-volume data, and hardware modules (like incubators and perfusion systems) to keep samples viable during experiments. The MEAs are label-free and real-time, allowing continuous monitoring of neural responses to drugs or genetic modifications.

Neuroscientists and pharmaceutical companies use 3Brain’s MEA systems for applications such as drug screening (e.g., evaluating how compounds modulate neural firing patterns), disease modeling (observing abnormal network activity in patient-derived brain organoids), and fundamental research (studying connectivity and synchronization in neural circuits). For example, in epilepsy research, an MEA can capture spontaneous seizure-like discharges in a dish and test anti-epileptic drug effects. In neurotoxicology, it can reveal if a chemical perturbs neural signaling. The rich data also help identify electrophysiological biomarkers – quantitative signatures of disease or drug action. By providing a bridge between cellular neuroscience and systems neuroscience in a controlled environment, 3Brain’s tools accelerate discovery while reducing reliance on animal models. Their technology exemplifies how microelectronics and neuroscience intersect to create powerful infrastructure for brain research and personalized medicine development.