Automated pipelines that test, build, and deploy code or models when changes are made.
Tools and Infrastructure
Control signal
A neural feature mapped to a specific BCI command or output.
Brain-Computer Interface
Cortical excitability
The ease with which cortical neurons can be activated, often modulated by stimulation protocols.
Neuromodulation
Cortical thickness
The distance between the white and pial surfaces of cortex, often used as a marker of structural integrity.
Neuroimaging
Cranial electrotherapy stimulation (CES)
Low-intensity electrical stimulation applied via ear clips or scalp to modulate mood or sleep.
Neuromodulation
Cross-frequency coupling
Interaction between neural oscillations at different frequencies, sometimes used as a control feature in BCIs.
Brain-Computer Interface
Cross-validation
Technique splitting data into subsets to estimate model generalizability.
Tools and Infrastructure
Crosstalk (neural recording)
Unwanted interference between recording channels or nearby electrodes.
Brain-Computer Interface
Current steering
Shaping current flow through multiple electrodes to focus or shift stimulation effects.
Neuromodulation
Cursor control BCI
Systems enabling cursor movement through decoded neural activity.
Brain-Computer Interface
Cybersecurity hardening (medical devices)
Enhancing device security to prevent breaches, tampering, or unauthorized data access.
General
Dashboard
Visual interface that aggregates metrics, trends, and alerts for monitoring systems or cohorts.
Tools and Infrastructure
Data acquisition system (DAQ)
Hardware-software stack that records biosignals (e.g., EEG, fNIRS, EMG) and streams them to a computer in real time.
Tools and Infrastructure
Data annotation protocol
Standardized rules for labeling signals, images, or behaviors consistently.
General
Data dictionary
Structured reference defining variables, units, formats, and permissible values.
Tools and Infrastructure
Data governance
Policies and processes that define how data is collected, stored, accessed, and used responsibly.
Tools and Infrastructure
Data harmonization
Processes that standardize datasets collected across devices, protocols, or study sites.
Tools and Infrastructure
Data ingestion service
Software that receives, validates, and routes incoming data streams from devices or APIs.
Tools and Infrastructure
Data lake
Large storage repository that holds raw, heterogeneous data (signals, logs, metadata) at scale.
Tools and Infrastructure
Data lifecycle management
Governance of data from collection through storage to deletion.
General
Data pipeline
End-to-end process that moves data from acquisition through cleaning, transformation, and storage.
Tools and Infrastructure
Data provenance
Documentation of where data came from and how it was processed across its lifecycle.
Tools and Infrastructure
Data pseudonymisation
The process of replacing personal identifiers with coded substitutes so data can be linked without revealing identity, while still allowing re-identification under controlled conditions.
Tools and Infrastructure
Data quality checks
Automated or manual tests verifying completeness, consistency, and validity of data.
Tools and Infrastructure
Data warehouse
Centralized, structured database optimized for analytics and reporting on curated datasets.
Tools and Infrastructure
De Novo classification
FDA pathway for first-of-kind devices with no predicate but low-to-moderate risk.
General
De-identification
Broad process of removing or generalizing personal identifiers to reduce privacy risk.
Tools and Infrastructure
Decoder calibration
Collecting training data to optimize BCI decoding performance.
Brain-Computer Interface
Decoder drift
Gradual changes in neural signal properties that reduce decoding accuracy unless updated.
Brain-Computer Interface
Decoding analysis (neuroimaging)
Using machine learning to predict stimuli, tasks, or states from brain activity patterns.
Neuroimaging
Deep TMS
TMS using specialized coils (e.g., H-coils) designed to reach deeper brain structures.
Neuromodulation
Deep brain stimulation (DBS)
Invasive neuromodulation using implanted electrodes in deep brain structures, typically driven by a subcutaneous stimulator.
Neuromodulation
Default mode network (DMN)
A large-scale brain network active at rest and deactivated during many goal-directed tasks.
Neuroimaging
Delta band (δ)
Slow brain oscillations typically around 0.5–4 Hz, prominent in deep sleep and some pathological states.
Neuroimaging
Delusion
Fixed, false belief not aligned with cultural norms and resistant to contradictory evidence.
Cognitive and Mental Health
Dementia
A syndrome of substantial cognitive decline that interferes with daily functioning, often progressive.
Cognitive and Mental Health
Deployment environment
The computational and physical setting where a system runs (clinic, cloud, OR, wearable).
General
Desensitization (neuromodulation)
Reduced responsiveness to repeated stimulation, requiring parameter adjustment.
Neuromodulation
Device artifact
Signal distortion introduced by hardware or electrical interference.
General
Device calibration
Procedure ensuring a device’s measurements remain accurate.
General
Device firmware
Embedded software running directly on neurotech hardware.
Tools and Infrastructure
Device lifecycle management
Coordinated oversight of versioning, maintenance, updates, and retirement of devices.
General
Diffuse optical tomography (DOT)
Optical imaging method reconstructing 3D maps of cortical hemodynamics using near-infrared light.
Neuroimaging
Diffusion tensor imaging (DTI)
A diffusion MRI method that models directional water diffusion to infer white matter pathways.
Neuroimaging
Diffusion-weighted imaging (DWI)
MRI technique measuring the diffusion of water molecules, sensitive to microstructural changes and acute stroke.
Neuroimaging
Digital biomarker
A quantifiable behavioral or physiological signal measured by digital tools that relates to health or disease.
Cognitive and Mental Health
Digital biomarker platform
Infrastructure that ingests sensor data, extracts features, and computes clinically relevant metrics.
Tools and Infrastructure
Digital cognitive biomarker
Behavioral or sensor-derived metric that reflects cognitive function in everyday environments.
Cognitive and Mental Health
Digital endpoint
A clinically meaningful metric derived from sensor data in trials or remote monitoring.
General
Digital health
Technology-enabled healthcare including apps, sensors, telehealth, and analytics.
General
Digital phenotyping engine
System extracting behavioral and physiological markers from continuous sensor data.
Tools and Infrastructure
Digital therapeutic
Software-based intervention with demonstrated clinical benefit, often delivered via apps or online platforms.
Cognitive and Mental Health
Digital twin (neural)
Computational model simulating a person’s neural system for prediction or personalization.
General
Directional lead
A stimulation lead with segmented contacts that steer current toward specific tissue regions.
Neuromodulation
Distributed computing framework
Infrastructure enabling parallel processing across multiple machines or clusters.
Tools and Infrastructure
Domain adaptation
ML methods aligning data distributions across subjects, sessions, or devices to improve generalization.
Stimulation of dorsal root ganglia to modulate sensory pathways and chronic pain.
Neuromodulation
Dose (neuromodulation)
The combination of parameters (intensity, frequency, duration, number of sessions) defining a stimulation regimen.
Neuromodulation
Dose optimization
Systematic adjustment of stimulation or therapy parameters to maximize benefit.
Neuromodulation
Dose-response curve
Relationship between stimulation intensity/duration and physiological or behavioral effects.
Neuromodulation
Double-blind trial
A study design in which neither participants nor investigators know which intervention each participant receives, reducing expectancy and observer bias.
General
Drift correction
Adjustment applied when sensors or baselines shift slowly over time.
Tools and Infrastructure
Duty cycle
The proportion of time stimulation is “on” versus “off” within a given period.
Neuromodulation
Dysphoria
A state of unease or dissatisfaction, often used to describe negative mood.
Cognitive and Mental Health
ETL / ELT pipeline
Extract-Transform-Load (or Load-Transform) workflow that ingests raw data and prepares it for analysis.
Tools and Infrastructure
Echo planar imaging (EPI)
Fast MRI acquisition method commonly used in fMRI and diffusion imaging.
Neuroimaging
Echo time (TE)
The time between excitation and signal readout, influencing MRI contrast.
Neuroimaging
Ecological momentary assessment (EMA)
Repeated, in-the-moment data collection in real-world settings via phones or wearables.
Cognitive and Mental Health
Edge AI
Running neural network inference directly on devices (e.g., wearables, implants) instead of cloud.
Tools and Infrastructure
Edge computing
Running inference or preprocessing on-device or near the sensor, rather than in the cloud.
Tools and Infrastructure
Edge-secure firmware
Cryptographically protected firmware on clinical devices to prevent tampering and unauthorized updates.
General
Edge-to-cloud architecture
Workflow distributing processing between local devices and cloud systems.
General
Effective connectivity
Directional influence one brain region exerts over another, often inferred with causal models.
Neuroimaging
Electrocardiography (ECG/EKG)
Measurement of cardiac electrical activity, often synchronized with neural recordings.